(-)-Zuonin A

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC₅₀s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively^[1]. In Vitro: (−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs^[1].
(−)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation^[1].