Actin is a 43 kDa protein that is very highly conserved between species. Actin has three main isotypes (α-actin, β-actin and γ-actin), which show > 90% amino-acid (aa) homology between isotypes and > 98% homology within members of a particular isotypic group. The majority of the isotype heterogeneity is located in the amino-terminal 30 residues. The amino-terminus of actin is located on the periphery of the double-helix in F-actin (4) and this site is also thought to interact with myosin (5).
Cytoskeleton, Inc. offers a large selection of highly pure and biologically active actin proteins, actin binding proteins, antibodies, buffers and research Biochem Kits™. Our Actin Biochem Kits allow researchers easy access to some of the most powerful in vivo and in vitro assays employed in the field. Many citations exist where these products have been used to solve some fundamental questions in biology. Detailed information can be found by clicking on each of the actin product categories.