Recombinant Rat SCF

Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor¹ is a paracrine regulator of germ cell development.² SCF has the ability to stimulate the growth of hematopoietic progenitor cells and to generate colony-forming cells (CFC) from highly enriched populations of hematopoietic cells.³ SCF is produced by the Sertoli cells and involved in the local regulation of spermatogenesis⁴ and liver regeneration.⁵ SCF in conjunction with interleukin-31 may play a significant role in airway remodeling by promoting the recruitment of bone marrow-derived fibroblast precursors into the lung with the capacity to promote lung myofibroblast differentiation.⁶