Recombinant Rat Jagged-1

Jagged 1 (JAG1) is a cell surface protein that functions in an embryologically important signaling pathway, known as the Notch signaling pathway, which is a highly conserved cell signaling system.¹ JAG1 plays an essential role in tissue formation during embryonic development of primitive organisms.² JAG1 is a strong candidate gene for Alagille syndrome (AGS)³ which is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region.⁴