Recombinant Mouse FZD4Recombinant Mouse FZD4
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Recombinant Mouse FZD4

Frizzled-4 (FZD4), also known as CD344 and EVR1, is a transmembrane glycoprotein of the Frizzled family within the G-protein coupled receptor superfamily. Members of this family encode seven transmembrane domain proteins that function as receptors for Wnt proteins. They can activate canonical Wnt/beta-catenin signaling as well as planar cell polarity and calcium flux pathways (1). FZD4 is particularly important in angiogenic Wnt pathway signaling and it is expressed in a variety of tissues (1). FZD4 is unusual in that it binds to Norrin, a non-wnt ligand, in addition to binding Wnt ligands (2). Mutations producing loss of function of either FZD4 or Norrin, result in blindness due to familial exudative vitreoretinopathy (FEVR). FZD4 also functions as a ligand-receptor pair to control vascular development in the retina and inner ear (3). FZD4 expression may play a critical role in responses to Wnt signaling in the tumor microenvironment (4).
Cat# Size Price Qty Buy
F1028-50ug 50ug £336.56

Additional Information

Property Value or Rating
Manufacturer Cat# F1028
Product Size 50ug
Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Manufacturer Leinco Technologies Inc
Alternate Names Frizzled-4 Frizzled4 Frizzled 4 Recombinant Mouse Frizzled-4 FZD4 Recombinant Mouse Frizzled-4 EVR1 FEVR FZD4S Fz-4 FzE4 GPCR MGC34390 CD344 EVR1 FEVR FZD4S Fz4 FzE4 GPCR MGC34390 CD344 EVR1 FEVR FZD4S Fz 4 FzE4 GPCR MGC34390 CD344 Recombinant Mouse Frizzled-4 Recombinant Protein Frizzled-4 EVR1 FEVR FZD4S Fz-4 FzE4 GPCR MGC34390 CD344 FZD4 Mouse Frizzled-4 Recombinant Mouse Frizzled-4 Recombinant Protein Frizzled4 EVR1 FEVR FZD4S Fz4 FzE4 GPCR MGC34390 CD344 FZD4 Mouse Frizzled4 Recombinant Mouse Frizzled4 Recombinant Protein Frizzled 4 EVR1 FEVR FZD4S Fz 4 FzE4 GPCR MGC34390 CD344 FZD4 Mouse Frizzled 4 Recombinant Mouse Frizzled 4 Recombinant Mouse Frizzled-4
Applications ELISA Cap
Storage -20°C to -70°C
Protein Frizzled-4

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