Recombinant Human TNF RII

TNF RII, also known as TNFRSF1B, is a transmembrane glycoprotein and member to the TNF receptor superfamily (1). It is limited primarily to hematopoietic cells and cells of the immune system and is produced naturally as a soluble form (sTNF RII) in various biological fluids (2). The soluble TNF receptor can bind TNF with high affinity and function as a TNF antagonist (3, 4). TNF RII is strongly expressed at the cartilage–pannus junction and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (1, 5). High plasma levels of sTNF RII were associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors (5). TNF RII has also been implicated in diabetes (6).