Recombinant Human TNF RII

Tumor necrosis factor receptor II (TNF-RII, TNFRSF1B, p75, CD120b) is a membrane glycoprotein in the TNF receptor superfamily. It is present on most cell types and is considered to play a prominent role in stimulation by TNF-α (1). TNF-RII proteins are expressed by hematopoietic cells including macrophages, neutrophils, lymphocytes, thymocytes and mast cells, as well as endothelial cells, cardiac myocytes and prostate cells (2). Soluble TNF-RII neutralizes the biological activities of TNF-α and TNF-β with equal efficiency (3).