Recombinant Human sTNF RI

Tumor necrosis factor receptor superfamily, member 1A, (TNFRI) also known as TNFRSF1A or CD120A is the principal receptor through which many of the pro-inflammatory activities of TNFα are mediated.² TNFRI contains a death domain through which it interacts with other death-domain proteins to promote cellular responses.² TNFRI is found in both membrane-bound and soluble forms. It interacts with membrane-bound or soluble forms of its ligand (TNFα), respectively. Binding of membrane-bound TNFα to the membrane-bound receptor is involved in cell survival, apoptosis, and inflammation by inducing receptor trimerization and activation. ⁴ Proteolytic processing of TNFRI yields the release of the soluble form of the receptor (TNFsRI), which inhibits inflammation via the interaction with free TNFα.