Recombinant Human PDGF-BB (P126-GRP)

Platelet-derived growth factor-BB homodimers (PDGF-BB), also known as GDGF and ODGF, is a member of the PDGF family. PDGFs are disulfide-linked dimers consisting of two polypeptide chains, designated PDGF-A and PDGF-B. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. They are stored in platelet α-granules and are released upon platelet activation. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β (1). PDGFR-α is a high-affinity receptor for each of the three PDGF forms, while PDGFR-β interacts with only PDGF-BB and PDGF-AB. PDGF functions as a local autocrine and paracrine growth factor (2). PDGF-BB plays an important role in the cellular metabolism of vascular wall by regulating the rate of M-CSF production in vascular smooth muscle cells (3). It is also a potent wound-healing hormone that accelerates incisional repair (4). PDGF-BB may induce coronary atherosclerotic disease formation by stimulating coronary artery smooth muscle cell migration and proliferation. It does that through agent-specific regulation of oxidative status and utilization of different signal transduction pathways (5). PDGF-BB is associated with excessive cell migration, proliferation and many growth-related diseases and may be a new prognostic indicator for patients with colorectal cancer (5-6).