Recombinant Human PDGF-AA (P125-GRP)

Platelet-derived growth factor-BB homodimers (PDGF-BB), also known as GDGF and ODGF, is a member of the PDGF family. PDGFs are disulfide-linked dimers consisting of two polypeptide chains, designated PDGF-A and PDGF-B. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. They are stored in platelet α-granules and are released upon platelet activation. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β.1 PDGFR-α is high-affinity receptor for each of the three PDGF forms, while PDGFR-β interacts with only PDGF-BB and PDGF-AB. PDGF functions as a local autocrine and paracrine growth factor.2 PDGF-AA is widely expressed in normal and transformed cells and is a potent mitogen for a wide range of cell types including fibroblast, smooth muscle and connective tissue.3 The PDGF-AA/receptor complex represents an important epithelial-mesenchymal interaction which plays a critical role in early lung branching morphogenesis.4 It is also an essential autocrine regulator for vascular endothelial growth factor (VEGF) expression, regulating its frequency and level during the transition from a precancerous lesion to advanced cancer.5