Recombinant Human IL-7 (I-189-GRP)

Interleukin 7 (IL-7), also known as Lymphopoietin 1, is a hematopoietic growth factor which affects primarily early B and T cells (1). It stimulates the differentiation of multipotent hematopoietic stem cells into lymphoid progenitor cells. IL-7 is important for proliferation during certain stages of B cell maturation, T and NK cell survival, development and homeostasis. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2 (2). In myeloid lineage cells, IL-7 up-regulates the production of pro-inflammatory cytokines and stimulates the tumoricidal activity of monocytes and macrophages. IL-7 has significant clinical and biomedical potential, such as cancer therapy and HIV infections (3). Human and murine IL-7 is cross-species reactive.