Recombinant Human IL-17 R

Interleukin-17 receptor (IL-17R), also known as CD217, is a cytokine receptor which binds interleukin-17 (1). Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC (2). IL-17R is expressed on a wide range of hematopoietic and non-hematopoietic tissues and cell lines, as well as cord blood lymphocytes, peripheral blood lymphocytes and thymocytes. Expression is also on B, T and NK cells, fibroblasts, epithelial cells, monocytes, macrophages and granulocytes. IL-17R signaling is critical for pulmonary neutrophil recruitment and host defense against Gram-negative bacteria through the coordinated release of G-CSF and CXC chemokine elaboration (3). IL-17/IL-17R play a critical role in regulating host susceptibility to Chlamydia infection in mice (4).