Recombinant Human EDA-A2

Ectodysplasin A (EDA) is a ligand of the tumor necrosis factor (TNF) family that has been shown to play a crucial role in ectodermal differentiation. EDA-A1 and EDA-A2 are the two main splice variants of EDA. ¹ EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). EDA-A1 and EDA-A2 are differentially expressed and play a role in epidermal morphogenesis.
EDA-A2 is a type III integral membrane protein with three CYS region at the N terminal region. ² EDA-A2 may be a promising agent for the gene therapy of osteosarcoma.