Recombinant Human CXCL16

CXC chemokine ligand 16 (CXCL16), also known as SR-PSOX, is a 20 kDa type I transmembrane protein. It acts as a scavenger receptor on macrophages, which specifically binds to oxidized low density lipoprotein, suggesting that it may be involved in pathophysiology such as atherogenesis. (1) CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo. It is found in liver tissue and influences the uptake, subcellular localization and cytokine profile induced by D oligonucleotides (2-3). It is produced by dendritic cells found in the T cell zones of lymphoid organs and by cells found in the red pulp of the spleen (4). Cells that bind and migrate in response to CXCL16 include several subsets of T cells and natural killer T (NKT) cells (4). Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. It may play a pro-inflammatory role in Inflammatory Bowel Disease (IBD), particularly Crohn's disease (5).