QuantiChrom™ Copper Assay KitQuantiChrom™ Copper Assay Kit
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QuantiChrom™ Copper Assay Kit

For quantitative determination of copper(II) ion and evaluation of drug effects on Cu metabolism.

• Sensitive and accurate. Linear detection range 7 μg/dL (10 μM) to 300 μg/dL (47 μM) copper in 96-well plate assay.

• Simple and high-throughput. The simple procedure can be readily automated as a high-throughput assay in 96-well plates for thousands of samples per day.

• Improved reagent stability and versatility. The optimized formulation has greatly enhanced reagent and signal stability. Cuvet or 96-well plate assay. 

Copper is an essential trace element. Copper-containing enzymes play important roles in iron and catecholamine metabolism, free radical scavenging, and in the synthesis of hemoglobin, elastin and collagen. Copper is mainly present in caeruloplasmin in the liver. Low levels of copper have been associated with mental retardation, depigmentation, anaemia, hypotonia and scorbutic changes in bone. Levels of copper are key diagnostic indicator of diseases such as Wilson’s disease, microcytic hypochromic anaemia and bone disease due to reduced collagen synthesis. Simple, direct and automation-ready procedures for measuring copper concentrations find wide applications in research, drug discovery and environmental monitoring. BioAssay Systems’ copper assay kit is designed to measure copper with no or minimal sample treatment. The improved method utilizes a chromogen that forms a colored complex specifically with copper ions. The intensity of the color, measured at 359nm, is directly proportional to copper concentration in the sample. The optimized formulation substantially reduces interference by substances in the raw samples.

Cat# Size Price Qty Buy
DICU-250 250 Tests £339.15

Additional Information

Property Value or Rating
Product Size 250 Tests
Manufacturer BioAssay Systems
Applications For quantitative determination of copper(II) ion and evaluation of drug effects on Cu metabolism.
Method OD359nm
Samples Biological, environment, food and beverage
Species All
Detection Limit 7 μg/dL (10 μM)
Storage 4°C
Shelf Life 6 months
References Assay: Copper in human cell (Pubmed).

2. Lull, ME et al (2008). Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatr Res. 63(6):638-44. Assay: Copper in Human plasma (Pubmed).

3. Bartnikas TB (2012) Known and potential roles of transferrin in iron biology. Biometals 25(4):677-86 . Assay: Copper in human protein (Pubmed).

4. Philips N et al (2012) Beneficial regulation of fibrillar collagens, heat shock protein-47, elastin fiber components, transforming growth factor-β1, vascular endothelial growth factor and oxidative stress effects by copper in dermal fibroblasts. Connect Tissue Res. 53(5):373-8. Assay: Copper in human cell (Pubmed).

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1. Piret JP et al (2012) Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape. Nanotoxicology 6:789-803. Assay: Copper in human cell (Pubmed).

2. Lull, ME et al (2008). Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatr Res. 63(6):638-44. Assay: Copper in Human plasma (Pubmed).

3. Bartnikas TB (2012) Known and potential roles of transferrin in iron biology. Biometals 25(4):677-86 . Assay: Copper in human protein (Pubmed).

4. Philips N et al (2012) Beneficial regulation of fibrillar collagens, heat shock protein-47, elastin fiber components, transforming growth factor-β1, vascular endothelial growth factor and oxidative stress effects by copper in dermal fibroblasts. Connect Tissue Res. 53(5):373-8. Assay: Copper in human cell (Pubmed).

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1. Piret JP et al (2012) Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape. Nanotoxicology 6:789-803. Assay: Copper in human cell (Pubmed).

2. Lull, ME et al (2008). Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatr Res. 63(6):638-44. Assay: Copper in Human plasma (Pubmed).

3. Bartnikas TB (2012) Known and potential roles of transferrin in iron biology. Biometals 25(4):677-86 . Assay: Copper in human protein (Pubmed).

4. Philips N et al (2012) Beneficial regulation of fibrillar collagens, heat shock protein-47, elastin fiber components, transforming growth factor-β1, vascular endothelial growth factor and oxidative stress effects by copper in dermal fibroblasts. Connect Tissue Res. 53(5):373-8. Assay: Copper in human cell (Pubmed).

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