(+)-Penbutolol

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM^[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na⁺ channel-blocking action^[2]. IC50 & Target: IC50: 0.74 μM (β-adrenoceptor)^[1]. In Vitro: (+)-penbutolol on the [Ca²⁺]_i-increase induced by LPC is concentration-dependent^[1].
(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10^-6 M, 5×10^-6 M and 10^-5 M, respectively)^[2].