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Ceramide phosphorylethanolamine

Sphingosylphosphorylethanolamine is analogous to sphingomyelin, containing an ethanolamine headgroup rather than a choline headgroup, and is thought to have similar structural functions. It has been found in some marine invertebrates, anaerobic bacteroides, some insects, and in the eukaryotic microorganism Oomycete but not in plants or mammals. It is thought that sphingosylphosphorylethanolamine may be produced when there is a lack of choline to make sphingomyelin1 and that it is probably localized in the plasma membrane, similar to sphingomyelin.2 The enzyme phosphatidylethanolamine:ceramide-phosphorylethanolamine transferase is deactivated by phospholipase C treatment but not by phospholipase A2 or phospholipase D.3
Cat# Size Price Qty Buy
1327 5 mg £187.85

Additional Information

Property Value or Rating
Product Size 5 mg
Manufacturer Matreya, LLC
Empirical Formula C43H87N2O6P (tricosanoyl)
Formula Weight 759.1
Solvent none
Source semisynthetic
Purity 98+%
Analytical Methods TLC
Natural Source Animal/Bovine buttermilk|Semi-synthetic
Solubility chloroform/methanol, 2:1
Physical Appearance A neat solid
Storage -20°C

1. R. Dawson and P. Kemp “Isolation of Ceramide Phosphorylethanolamine from the Blowfly Calliphora erythrocephala” Journal of Biochemistry, Vol. 106 pp. 319-320, 1968 
2. R. Moreau et al. “Identification of Ceramide-Phosphorylethanolamine in Oomycete Plant Pathogens: Pythium ultimum, Phytophthora infestans, and Phytophthora capsici” Lipids, Vol. 33(3) pp.307-317, 1998 
3. M. Nikolova, D. Petkova, K. Koumanov “Influence of phospholipid environment on the phosphatidylethanolamine: ceramide-phosphorylethanolamine transferase activity in rat liver plasma membranes.” International Journal of Biochemistry, Vol. 24(3) pp. 447-453, 1992

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