Monosialoganglioside, GM4, (egg), (NH4+ salt)Monosialoganglioside, GM4, (egg), (NH4+ salt)
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Monosialoganglioside, GM4, (egg), (NH4+ salt)

GM4

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM4 is a monosialoganglioside located primarily in the central nervous system and was found to be a major component of myelin gangliosides.4 It was also found to be a specific marker for human myelin and oligodendroglial perikarya. However, in chicken cerebellum, GM4 is associated with astrocytes, and not with myelin. GM4 has been found to be the major ganglioside in chicken egg yolk, chicken embryonic liver, and frog liver.
Cat# Size Price Qty Buy
1535 0.5 mg £421.88

Additional Information

Property Value or Rating
Product Size 0.5 mg
Manufacturer Matreya, LLC
Empirical Formula C57H106N2O17 • NH3 (2-hydroxydocosanoyl)
CAS# 66456-69-7
Formula Weight 1108.5
Source natural
Purity 98+%
Analytical Methods TLC
Natural Source Animal/Egg|Animal/Chicken
Solubility chloroform/methanol, 2:1; forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm et al. (eds.), “Structure and Function of Gangliosides” New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff, “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277:29, pp. 25859-25862, 2002 
3. S. Birkle et al. “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003 
4. Li et al. “Association of GM4 ganglioside with the membrane surrounding lipid droplets in shark liver” Journal of Lipid Research, Vol. 43 pp. 1019-1025, 2002

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