Monosialoganglioside GM3, (NH4+ salt)Monosialoganglioside GM3, (NH4+ salt)
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Monosialoganglioside GM3, (NH4+ salt)

GM3

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. GM3 is the main ganglioside of human fibroblasts and can regulate fibroblast and epidermal growth factors4 and is also able to regulate the adhesion and migration of several carcinoma cell lines. GM3 was also shown to inhibit tumor cell invasion. GM3 can induce human promyelocytic leukemia HL-60 cells to differentiate to monocyte/macrophage lineage instead of granulocytes.5
Cat# Size Price Qty Buy
1503 1 mg £164.06

Additional Information

Property Value or Rating
Product Size 1 mg
Manufacturer Matreya, LLC
Empirical Formula C64H118N2O21 • NH3 (tricosanoyl)
CAS# 54827-14-4
Formula Weight 1268.7
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source Animal/Bovine buttermilk
Solubility chloroform/methanol, 2:1; forms micellar solution in water
Physical Appearance A neat solid
Storage -20°C
References

1. L. Svennerholm, et al. (eds), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff, J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002 
3. S. Brickle, G. Zeng, L. Gaol, R.K. Yu, J. Aubry, Biochimie, 85, 455-463, 2003 
4. E.G. Bremer, J. Schlessinger, and S. Hakomori, J. Biol. Chem., Vol. 261, pp. 2434-2440, 1986 
5. T. Chung, H. Choi, Y. Lee, and C. Kim, Glycobiology, Vol. 15:3, pp. 233-244, 2004

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