Mixed Gangliosides,Purified, (bovine brain), (nominal %--GD1a 55%,GM1 18%,GD1b 15%,GT1b 10%,others 2%)

Mixed Gangliosides

This product contains a natural mixture of gangliosides (approximately 98% GM1, GD1a, GD1b, and GT1b) found in the central nervous system of adult bovine. The ratio of different gangliosides changes according to age, species, and organ. Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. Gangliosides act as receptors for various toxins and bacteria, accumulate in different tumors, and aid in many neuronal functions. Therefore they are very important in therapeutic processes.
Cat# Size Price Qty Buy
1065 25 mg £253.13

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Source natural
Purity 98+%
Analytical Methods TLC
Natural Source bovine
Solubility chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
Physical Appearance solid
Storage -20°C
Dry Ice No
Hazardous No
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. T. Kolter, R. Proia, K. Sandhoff. Combinatorial Ganglioside Biosynthesis. J. Biol. Chem. July Vol. 277, No. 29, pp. 25859-25862, 2002 
3. S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry, Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003

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