Methyl 10(E),12(Z)-OctadecadienoateMethyl 10(E),12(Z)-Octadecadienoate
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Methyl 10(E),12(Z)-Octadecadienoate

Methyl ester of CLA (10-trans, 12-cis)

This product is a methyl ester and is ideal as a gas chromatography standard. 10(E),12(Z)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in lipids originating in ruminant animals, including dairy products. It has several biological properties including anti-carcinogenic activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances which protect cells from the detrimental effects of peroxides. Animals fed a diet containing high levels of CLA have been observed to have improved feed efficiency (lean body mass increased while body fat decreased) and this seems to be due, mainly or exclusively, to the 10(E),12(Z)- Octadecadienoic acid.2 However, this isomer appears to increase oxidative stress and inflammatory biomarkers in obese men, which can lead to insulin resistance.3,4 10(E),12(Z)-Octadecadienoic acid increases LDL:HDL cholesterol and total:HDL cholesterol in humans.
Cat# Size Price Qty Buy
1254 25 mg £138.55

Additional Information

Property Value or Rating
Product Size 25 mg
Manufacturer Matreya, LLC
Empirical Formula C19H34O2
CAS# 21870-97-3
Formula Weight 294.5
Source synthetic
Purity 98+%
Analytical Methods GC, TLC
Natural Source Synthetic
Solubility ethanol, methanol, hexane, chloroform
Physical Appearance A neat liquid
Storage -20°C

1. Helen B. MacDonald, Journal of the American College of Nutrition, Vol. 19, No. 90002, 111S-118S, 2000
2. Yanwen Wang and Peter JH Jones, The American Journal of Clinical Nutrition, June, Vol. 79, No. 6, 1153S-1158S, 2004 
3. Ulf Risérus, MMed; Samar Basu, PhD; Stefan Jovinge, MD, PhD; Gunilla Nordin Fredrikson, PhD; Johan Ärnlöv, MD; Bengt Vessby, MD, PhD,Circulation 106:1925, 2002 
4. Soonkyu Chung, J. Mark Brown, J. Nathan Provo, Robin Hopkins and Michael K. McIntosh, The Journal of Biological Chemistry, September, Vol. 280: 38445, 2005

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