β-Melanocyte Stimulating Hormone (MSH), human (TFA)

β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist^[1]. IC50 & Target: Melanocortin-4 receptor (MC4-R)^[1] In Vitro: β-Melanocyte Stimulating Hormone (MSH), human (β-MSH) has high affinity at both human MC4-R transfected into CHO cells (K_i=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (K_i=5.0±0.4 nM)^[1].