Lecithin, (egg)/ml, 1 ml chloroformLecithin, (egg)/ml, 1 ml chloroform
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Lecithin, (egg)/ml, 1 ml chloroform

Phosphatidylcholine; PC

This product is a high purity phosphatidylcholine (PC) containing a natural mixture of fatty acids acylated to the sn-1 and sn- 2 positions. PC is a major component of biological membranes, especially in the outer leaflet, often composing almost 50% of the total phospholipids.{139} It is a vital component in membrane bilayers and is the main phospholipid circulating in plasma. PC plays an important role in membrane-mediated cell signaling by generating diacylglycerols and phospholipids.{50622} Phospholipase D is an enzyme that cleaves off the choline head group, converting PC to phosphatidic acid, while phospholipase C cleaves off the phosphate group leaving diacylglycerol. PC is the biosynthetic precursor of sphingomyelin, phosphatidylethanolamine, lyso-phosphatidylcholine, and platelet-activating factor. The choline headgroup is an essential nutrient in animals although it can be synthesized by methylating phosphatidylethanolamine to phosphatidylcholine and then cleaving the headgroup with phospholipase D.{29456} Tumor cells appear to have increased synthesis of PC and this may be a potential target for cancer therapy. Another function of PC is the activation of enzymes such as the enzyme 3- hydroxybutyrate dehydrogenase which must be bound to phosphatidylcholine before it can function optimally.
Cat# Size Price Qty Buy
1044 50 mg/ml, 1ml £70.31

Additional Information

Property Value or Rating
Product Size 50 mg/ml, 1ml
Manufacturer Matreya, LLC
Empirical Formula C44H84NO8P (oleoyl)
CAS# 8002-43-5
Formula Weight 786.1
Solvent chloroform
Source natural
Purity 98+%
Analytical Methods TLC
Natural Source Animal/Egg|Animal/Chicken
Solubility chloroform, ethyl ether, ethanol
Physical Appearance A neat liquid
Storage -20°C
References

1. M. Billah and J. Anthes “The regulation and cellular functions of phosphatidylcholine hydrolysis” Biochemistry Journal, Vol. 269 pp. 281-291, 1990 
2. J. Exton “Signaling through Phosphatidylcholine Breakdown” The Journal of Biological Chemistry, Vol. 265(1) pp. 1-4, 1990 
3. Z. Li and D. Vance “Phosphatidylcholine and choline homeostasis” Journal of Lipid Research, Vol. 49 pp. 1187-1194, 2008

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