DR6 (NT) Blocking Peptide
£103.13
DR6 (NT) Blocking Peptide (D280-50ug)
Product
| Cat # D280-50ug | Size 50 µg |
Price
£103.13
|
Qty
|
Description
Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro.1 DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK.
Specifications
| Manufacturer Cat# | D280 |
|---|---|
| Product Size | 50 µg |
| Concentration | 0.2 mg/ml |
| Formulation | This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. |
| Alternate Names | Blocking Peptide Death Receptor 6 TNFRSF21 DR6 Human DR6 DR6 (NT) Blocking Peptide |
| Target | Death Receptor 6 |
| Storage | Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | Death Receptor 6 |