Disialoganglioside GD1a, (bovine brain)Disialoganglioside GD1a, (bovine brain)
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Disialoganglioside GD1a, (bovine brain)

GD1a

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GD1a is one of the major brain gangliosides. It is a coreceptor of Toll-like receptor 2 signaling3 and it inhibits concanavalin A-induced 45Ca2 + uptake although it is not cytotoxic nor does it significantly alter the rate of Ca2 + efflux. Along with other gangliosides GD1a enhances tumor cell proliferation, invasion, and metastasis. It is a receptor for cholera toxin and contributes to the sodium channel functional variability within and between neuronal cells. GD1a causes a significant increase in the responsiveness of epidermal growth factor receptors, a condition that is often associated with the formation of tumors.4
Cat# Size Price Qty Buy
1062 5 mg £276.56

Additional Information

Property Value or Rating
Product Size 5 mg
Manufacturer Matreya, LLC
Empirical Formula C84H148N4O39•2NH3
CAS# 12707-58-3
Formula Weight 1838+2NH3 (stearoyl)
Source natural
Purity 98+%
Analytical Methods TLC; identity confirmed by MS
Natural Source bovine
Solubility chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
Physical Appearance solid
Storage -20°C
Dry Ice No
Hazardous No
References

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980 
2. S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry, Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003 
3. Shuang Liang et al, The Journal of Biological Chemistry, March, Vol. 282 pp. 7532-7542, 2007 
4. Yihui Liu, Ruixiang Li and Stephan Ladisch, The Journal of Biological Chemistry, August, Vol. 279 pp. 36481-36489, 2004

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