anti- TNF alpha antibody

anti- TNF alpha antibody

TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Cat# Size Price Qty Buy
FNab08815 100µg £280.00

Additional Information

Property Value or Rating
Product Size 100µg
Manufacturer FineTest
Antibody Type monoclonal
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Physical Appearance liquid
Purification Protein A+G purification
Purity ≥95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2b
Immunogen tumor necrosis factor(TNF superfamily, member 2)
Alternate Names Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNF-a, TNFSF2, Tumor necrosis factor
Calculated MW 22 kDa
Protein ID P01375
Clone 2A9
Reactivity Human, Mouse, Rat
Applications ELISA, FC, IHC, WB
Recommended dilution WB: 1:500-1:5000; IHC: 1:200-1:1000

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