anti- STAT3 antibody

anti- STAT3 antibody

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3.
Cat# Size Price Qty Buy
FNab08300 100µg £245.00

Additional Information

Property Value or Rating
Product Size 100µg
Manufacturer FineTest
Antibody Type monoclonal
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Physical Appearance liquid
Purification Protein A+G purification
Purity ≥95% as determined by SDS-PAGE
Host Mouse
Isotype IgG2a
Immunogen signal transducer and activator of transcription 3(acute-phase response factor)
Alternate Names Acute phase response factor, APRF, FLJ20882, HIES, STAT3
Calculated MW 88 kDa
Protein ID P40763
Clone 6A9
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC, IP, WB
Recommended dilution WB: 1:2000-1:20000; IP: 1:1000-1:10000; IHC: 1:50-1:500; IF: 1:50-1:500
Gene ID 6774

Related Documents