Anti-Human TACE Purified No Carrier Protein (Clone: 111633)

TACE (tumor necrosis factor-α-converting enzyme) is a pleiotropic metalloprotease also known as ADAM17 that is found to be constitutively expressed by intestinal epithelial cells.¹ TACE is a major sheddase of TNF-α and its receptors, essential for the generation of soluble, mature molecules.² TACE as a promising target of epidermal growth factor receptor (EGFR) axis inhibition in colorectal cancer (CRC)³ and a principal target for the treatment of TNF-dependent pathologies.⁴