Anti-Human IL-4 - Purified <i>in vivo</i> GOLDâ„¢ Functional Grade
Anti-Human IL-4 - Purified <i>in vivo</i> GOLDâ„¢ Functional Grade (I-1163-GRP)
Products
Description
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-1163 |
| Concentration | ≥ 2.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody Interleukin-4 BCGF BCDF B Cell Stimulating Factor BSF-1 MP4-25D2 IL-4 Human Anti-Human IL-4 - Purified Low Endotoxin Functional Formulation |
| Isotype | IgG1 κ |
| Clone | MP4-25D2 |
| Antibody Type | Monoclonal |
| Applications | CyTOF®, IHC, N, WB |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | IL-4 |