Anti-Human Bcl-2 (NT)

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.2 Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis.2,3 These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis.4 It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad.5 Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.4,6