anti- DIABLO antibody

anti- DIABLO antibody

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.
Cat# Size Price Qty Buy
FNab02384 100µg £210.00

Additional Information

Property Value or Rating
Product Size 100µg
Manufacturer FineTest
Antibody Type polyclonal
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Physical Appearance liquid
Purification Immunogen affinity purified
Purity ≥95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Immunogen diablo homolog(Drosophila)
Alternate Names DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3
Calculated MW 20 kDa
Protein ID Q9NR28
Reactivity Human, Mouse, Rat
Applications ELISA, IHC, IP, WB
Recommended dilution WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200
Gene ID 56616

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