Anti-Cdc42 - Mouse Mab (ACD04-GRP)

Cdc42 (mol. wt. 21 kDa) belongs to the Rho-family of small G-proteins. The Rho family consists of at least 22 members, the most extensively characterized of which are the Rac1, RhoA and Cdc42 proteins. In common with all other small G-proteins, Rho family proteins act as molecular switches that transmit cellular signals through an array of effector proteins. The family mediates a diverse number of cellular responses including cytoskeletal reorganization, regulation of transcription, apoptosis and neuronal morphology. Proteins within the Rho-family share 40-95% amino acid identity within their GTPase domains.