1,2-Distearoyl-phosphatidylethanolamine-methyl-polyethyleneglycol conjugate

DSPE-MPEG-2000 (Na+ salt)

This product has been used for creating micelles that are able to carry drugs with low solubility. DSPE-MPEG-2000 has proven exceptionally useful due to certain characteristics such as good stability, longevity, and ability to accumulate in areas with abnormal vasculature, including tumors2,3 which have leaky vasculature. This product can be enhanced by the addition of various groups such as attaching specific targeting ligand molecules, imaging agents or surfactants to further increase the solubility.1
Cat# Size Price Qty Buy
1439 100 mg £140.63

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C43H83NO10P(C2H4O)45 • Na
CAS# 147867-65-0
Formula Weight 2810.4
Solvent none
Source synthetic
Purity 98+%
Analytical Methods TLC
Natural Source Synthetic
Solubility chloroform
Physical Appearance A neat solid
Storage -20°C
References

1. R. Sawant and V. Torchilin “Polymeric micelles: polyethylene glycol-phosphatidylethanolamine (PEG-PE)-based micelles as an example” Methods of Molecular Biology, Vol. 624 pp. 131-149, 2010 
2. A. Lukyanov, Z. Gao, and V. Torchilin “Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery” Journal of Control Release, Vol. 91(1-2) pp. 97-102, 2003 
3. S. Shaguna et al. “RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer” Molecular Therapy, 2011, doi:10.1038/mt.2011.21

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