1,2-Dimyristoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)1,2-Dimyristoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)
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1,2-Dimyristoyl-sn-glycero-3-phosphatidic acid, (Na+ salt)

DMPA

This phosphatidic acid (PA) is a well-defined phospholipid acylated with C14:0 fatty acids at the sn-1 and sn-2 positions. DMPA has been used to study the phosphatidic acid domains in membranes and the effect of divalent counterions.1 PA is an important acidic lipid that is only found in relatively small amounts in comparison to other lipids. Phosphatidic acid acts as the precursor to a number of phospholipids and triacylglycerols, is integral in forming the shape of cellular membranes,2 has roles in cellular signaling,3 and has a role in vesicle fission and fusion. PA is generally synthesized by the acylation of glycerophosphate but can also be synthesized by the phosphorylation of 1,2-diacyl-sn-glycerol or the hydrolysis of phosphatidylcholine. PA can be converted to diacylglycerols which are important cellular signaling agents.4 The metabolism of phosphatidic acid has been shown to change due to external stimuli in the pathogen Trypanosoma cruzi and this could be used to develop a treatment for this disease.5
Cat# Size Price Qty Buy
1428 100 mg £84.38

Additional Information

Property Value or Rating
Product Size 100 mg
Manufacturer Matreya, LLC
Empirical Formula C31H60O8P•Na
CAS# 80724-31-8
Formula Weight 615
Source synthetic
Purity 98+%
Analytical Methods TLC
Solubility chloroform/methanol/acetic acid, 4:1:0.1
Physical Appearance solid
Storage -20°C
Dry Ice No
Hazardous No
References

1. J. Faraudo and A. Travesset “Phosphatidic Acid Domains in Membranes: Effect of Divalent Counterions” Biophysical Journal, Vol. 92 pp. 2806-2818, 2007 
2. E. Kooijman et al. “Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid” Traffic, Vol. 4(3) pp. 162-174, 2003 
3. K. Athenstaedt and G. Daum “Phosphatidic acid, a key intermediate in lipid metabolism” European Journal of Biochemistry, Vol. 266 pp. 1-16, 1999 
4. M. Hodgkin et al. “Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?” Trends in Biochemical Sciences, Vol. 23(6) pp. 200-204, 1998 
5. A. Gimenez et al. “Regulation of Phosphatidic Acid Levels in Trypanosoma cruzi” Lipids, vol. 46 pp. 969-979, 2011

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