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The 1.4 nm Nanogold® particle is a gold compound: it is not just adsorbed to proteins, like colloidal gold, but covalently reacts at specific sites under mild buffer conditions.The Nanogold® particle is covalently and specifically linked to a hinge thiol on Fab' or IgG. The conjugate therefore has excellent stability compared to colloidal gold-antibody preparations. It is the first probe offered as a Fab' conjugate, which is the smallest gold-antibody probe commercially available.