SiR-azide (CY-SC009)

SiR-azide is the 3-azidopropyl derivative of the fluorophore silicon rhodamine (SiR)1) . Sir-azide reacts with terminal alkyne derivatives in the presence of copper (I) to form 1,2,3-triazoles linkage. It can also react with strained alkynes such as DIFO or DIBO without the need of copper. Small molecules, peptides, oligonucleotides or proteins bearing the appropriate alkyne can be conjugated to SiRazide. The key features of SiR-azide are i) far-red absorption and emission wavelengths, ii) high extinction coefficient, iii) high photostability, iv) compatibility with superresolution microscopy (STED & SIM). The combination of those properties put SiR-azide at the leading edge of excellence.