Recombinant Mouse PD-1 (P612-GRP)

Mouse Programmed Death-1 (PD-1)is an immune checkpoint receptor that regulates the system encoded by the Pdcd1 gene and functions similarly to its human counterpart. Its primary function involves regulating the immune system by inhibiting T-cell activation. This process is crucial for promoting self-tolerance and minimizing autoimmune reactions. This receptor is primarily found on activated T and B lymphocytes. There are differences between mouse PD-1 and human PD-1 in terms of how they're expressed, regulated, and interact with ligands 1, 2. It is crucial to understand the regulation of PD-1 expression, including the impact of genetic and epigenetic factors, for the development of immune-based therapies1 . Mouse PD-1 is a tool that enables us to study how the immune system is modulated and advance therapies that target the interaction between PD-1 and PD-L1 3 - 6 . Purified Mouse PD-1 Protein can be used for applications such as assays and binding studies, which help us understand how immune checkpoints work and explore potential immunotherapeutic strategies targeting PD-1/PD-L1 interactions7 . By studying mouse models, we can gain insights into treatments for cancer and autoimmune diseases. It's crucial to understand the species-specific differences in PD-1 biology to effectively translate findings from mouse models into human models.