Recombinant Human Plasma Selectin (P-selectin) (P251-50ug)

Plasma Selectin (P-selectin), also known CD62P and GMP-140, is a cell adhesion molecule and a member of the Selectin family. It is found in granules in endothelial cells and activated platelets. In unactivated endothelial cells, it is stored in granules Weibel-Palade bodies and α-granules in unactivated platelets (1). The P-selectin ligand, PSGL-1, plays an essential role in the initial recruitment of leukocytes to the site of injury during inflammation. During inflammation, when endothelial cells are activated by molecules such as histamine or thrombin, within minutes, P-selectin moves from an internal cell location to the endothelial cell surface. Thrombin is one trigger which can stimulate endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in the release of P-selectin (2). Acting in cooperation with L-selectin, P-selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic “rolling” of the leukocytes on the endothelium (3). P-selectin-mediated adhesion is an important factor in the development of early atherosclerotic lesions (1).