Recombinant Human PEDF (P232-GRP)

Pigment Epithelium-Derived Factor (PEDF) is a 50 kDa glycoprotein member of the serpin family known for its multifunctional properties, including neurotrophic, anti-angiogenic, and anti-tumor activities. Unlike inhibitory serpins, PEDF does not inhibit proteases but exerts its effects by inducing apoptosis in proliferating endothelial cells, thus suppressing angiogenesis. PEDF also antagonizes angiogenic factors such as VEGF and FGF-2, contributing to its anti-angiogenic role. Its neuroprotective function is mediated by preventing apoptosis in neurons caused by oxidative stress and neurotoxins. PEDF exerts its biological activities through a high-affinity interaction with its unique cell surface receptor, PEDF-R, which possesses phospholipase activity. This receptor-mediated signaling is key for PEDF's diverse roles, including inhibition of tumor growth and vascular-related neurodegenerative diseases like age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). The broad therapeutic potential of PEDF extends to various angiogenesis-dependent conditions, including cancer.