Recombinant Human NT-4 (N118-GRP)

Neurotrophin 4 (NT-4), also known as NT-5, is a member of the NGF family and is related to β-NGF, BDNF and NT-3.1 It promotes the development and survival of selected peripheral and CNS neurons. Several aspects distinguish NT-4 from other members of the neurotrophin family. It is the most divergent member and, in contrast to the other neurotrophins, its expression is ubiquitous and appears to be less influenced by environmental signals. NT-4 levels are highest in the prostate, with lower levels in thymus, placenta and skeletal muscle. It signals predominantly through the TrkB receptor tyrosine kinase. Knock-out mice lacking expression of NT-4 show long-term memory defects.3 In addition, NT-4 promotes the proliferation of keratinocytes and accelerates hair follicle regression.4 NT-4 is secreted by activated T cells and granulocytes at sites of inflammation where it contributes to tissue regeneration.5