Recombinant Human MIA-2 (M1121-GRP)

MIA2 functions as a tumor suppressor in hepatocellular carcinoma. It is a novel acute phase protein predominantly expressed in hepatocytes of the liver. MIA2 expression increases in response to liver damage associated with chronic liver diseases and is significantly elevated in patients with severe fibrosis. The protein is induced by key mediators such as IL-6, TGF-β, and factors present in conditioned medium from activated hepatic stellate cells, highlighting its role in liver pathology and fibrotic responses. This makes MIA2 a critical marker and functional player in liver health and disease.