Recombinant Human Maspin (SERPINB5) (M1221-GRP)

Maspin is a tumor suppressor serine protease inhibitor (serpin) predominantly produced by myoepithelial cells, known for its ability to inhibit tumor cell motility, invasion, angiogenesis, and metastasis in various cancer models. Clinical research consistently links maspin expression to improved outcomes in cancers such as prostate, breast, and pancreatic cancer, where it plays a regulatory role in cell adhesion and apoptosis, as well as epithelial cell homeostasis. Importantly, maspin’s prognostic significance extends to pulmonary adenocarcinoma and non-small cell lung cancer, with higher nuclear maspin correlating with better patient survival rates and reduced tumor progression. Beyond its cytoplasmic and nuclear activities, maspin can be secreted via exosomes, suggesting potential applications in novel cancer diagnostics and therapeutics.