Recombinant Human IL-32α
£5,615.63
Recombinant Human IL-32α (I-879-1mg)
Product
| Cat # I-879-1mg | Size 1 mg |
Price
£5,615.63
|
Qty
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Description
IL-32 is approximately 26kD and is a pro-inflammatory cytokine that can induce cells of the immune system to secrete inflammatory cytokines including TNFα. IL-32 can also support osteoclast differentiation by regulating the MAPK/ERK pathway and the actin cytoskeleton. IL-32 can exist in at least four differentially spliced isoforms (α, β, γ and δ) with IL-32α being the shortest and most abundant of the four variants. Remarkably, it does not share sequence homology with known cytokine families and is highly expressed in immune tissues. Elevated levels of IL-32 are present in patients with coronary artery disease and endometriosis and may play a role in other autoimmune and inflammatory diseases such as rheumatoid arthritis. In a recent lung cancer study, the inhibitory effects of IL-32γ on tumor development were associated with inhibition of the STAT5 pathway which ultimately demonstrated that IL-32γ negatively regulates tumor development suggesting that IL-32γ has therapeutic potential for use in the treatment of cancer progression.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-879 |
| Product Size | 1 mg |
| Alternate Names | Interleukin 32 a alpha Recombinant Human IL-32a a alpha IL-32a a alpha IL32a a alpha IL 32a a alpha Recombinant Human IL-32a a alpha IL-32a alpha IL-32a Interleukin 32 IL-32 Human IL-32 Mouse IL-32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alpha-inducing factor TNFa a alpha inducing factor IL32a alpha IL32a Interleukin 32 IL32 Human IL32 Mouse IL32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alphainducing factor TNFa a alpha inducing factor IL 32a alpha IL 32a Interleukin 32 IL 32 Human IL 32 Mouse IL 32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alpha inducing factor TNFa a alpha inducing factor Recombinant Human IL-32a a alpha Interleukin 32 a alpha,IL-32a alpha IL-32a Interleukin 32 IL-32 Human IL-32 Mouse IL-32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alpha-inducing factor TNFa a alpha inducing factor IL-32a a alpha Human Recombinant Human IL-32a a alpha Interleukin 32 a alpha,IL32a alpha IL32a Interleukin 32 IL32 Human IL32 Mouse IL32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alphainducing factor TNFa a alpha inducing factor IL32a a alpha Human Recombinant Human IL32a a alpha Interleukin 32 a alpha,IL 32a alpha IL 32a Interleukin 32 IL 32 Human IL 32 Mouse IL 32 Interleukin 32 a alpha NK4 Tumor necrosis factor a alpha inducing factor TNFa a alpha inducing factor IL 32a a alpha Human Recombinant Human IL 32a a alpha Recombinant Human IL-32a a alpha |
| Target | IL-32 Alpha |
| Antigen | IL-32α is secreted by T cells, natural killer cells, dendritic cells, and keratinocytes. |
| Storage | -20°C |
| Protein | IL-32 Alpha |