Recombinant Human IL-1 RI

Interleukin-1 receptor, type I (IL1R1), also known as CD121a, is a transmembrane glycoprotein and member of the IL-1 receptor family. As important mediators involved in many immune and inflammatory responses, the agonists IL-1α and IL-1β bind to IL1R1, leading to the signal transduction and activation of NF-κ B. IL1R1 also forms a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 which is indispensible for the signaling processes (1). IL1R1 has been shown to interact with PIK3R1, Myd88 and IL1RAP (2-4). It is expressed predominantly by T cells, fibroblasts and endothelial cells.