Recombinant Human IL-1α
Recombinant Human IL-1α (I-182-GRP)
Products
Description
IL-1R1 is an 80 kD transmembrane glycoprotein and a member of the Ig superfamily. IL-1 binds both IL-1R1 and IL-1R2. The ligands IL-1α and IL-1β only commence when binding IL-1R1 because IL-1R2 acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1β, thereby reducing their biological effects. Binding of the ligands to IL-1R1 is enhanced by an accessory protein, IL-1R-AcP. IL-1α can exist as either a 31 kD precursor or an 18 kD mature form. IL-1α is a proinflammatory cell-associated cytokine and IL-1β is a 17.5 kD proinflammatory secreted cytokine. Both IL-1α and IL-1β bind to the same receptor and have similar properties that include stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Furthermore, IL-1β mediates a variety of immune and inflammatory responses. IL-1β is a major cause of severe inflammation in the mouse model of Crohn’s Disease, which makes IL-1β an important target for this disease.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-182 |
| Formulation | This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. |
| Alternate Names | Interleukin-1a a alpha Interleukin1a a alpha Interleukin 1a a alpha Recombinant Human IL-1a a alpha IL-1a a alpha IL1a a alpha IL 1a a alpha Recombinant Human IL-1a a alpha Hematopoietin-1 Lymphocyte-Activating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF Hematopoietin1 LymphocyteActivating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF Hematopoietin 1 Lymphocyte Activating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF Recombinant Human IL-1a a alpha Recombinant Protein Interleukin-1a a alpha Hematopoietin-1 Lymphocyte-Activating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF IL-1 Alpha Human IL-1a a alpha Recombinant Human IL-1a a alpha Recombinant Protein Interleukin1a a alpha Hematopoietin1 LymphocyteActivating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF IL1 Alpha Human IL1a a alpha Recombinant Human IL1a a alpha Recombinant Protein Interleukin 1a a alpha Hematopoietin 1 Lymphocyte Activating Factor LAF Endogenous Pyrogen EP Leukocyte Endogenous Mediator LEM Mononuclear Cell Factor MCF IL 1 Alpha Human IL 1a a alpha Recombinant Human IL 1a a alpha Recombinant Human IL-1a a alpha |
| Storage | -20°C to -70°C |
| Protein | IL-1α |