Recombinant Human IGF-I (Previously QED Part No.: 20802P) (I-180-500ug)

IGFs (Insulin-like growth factors) are polypeptide growth factors that prompt cell growth and survival. Produced primarily by the liver, they affect muscle, bone, and cartilage tissues. As part of the insulin gene family, IGFs are structurally similar to insulin but possess greater growth-promoting activity. IGF-I and IGF-II are regulated by growth hormone and placental lactogen, respectively. They signal via the tyrosine kinase type I receptor and are created from inactive precursor proteins through proteolytic processing. This process involves the removal of N-terminal and C-terminal propeptide regions, transforming them into their mature, active forms. The IGFs' ability to stimulate proliferation makes them crucial for various developmental and regenerative processes in the body. The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half‑life and modulating its interactions with receptors.