Recombinant Human Growth Hormone Receptor
£473.44
Recombinant Human Growth Hormone Receptor (G643-50ug)
Product
| Cat # G643-50ug | Size 50 µg |
Price
£473.44
|
Qty
|
Description
Growth hormone receptor, also known as GHR is a 54 kDa transmembrane receptor and a member of the class I cytokine receptor family. Biologically active growth hormone binds to GHR, which dimerizes to activate an intracellular signal transduction pathway leading to synthesis and secretion of IGF1. In plasma, IGF1 binds to the soluble IGF1 receptor (IGF1R). At target cells, this complex activates signal-transduction via the JAK/STAT pathway, which results in the mitogenic and anabolic responses that lead to growth (1). GHR has also been shown to interact with SGTA, PTPN11 and CISH (2-4). Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism) (5).
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | G643 |
| Product Size | 50 µg |
| Formulation | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
| Alternate Names | Growth Hormone Receptor Recombinant Human Growth Hormone Receptor/Fc GHR Recombinant Human Growth Hormone Receptor/Fc GHBP Recombinant Human Growth Hormone Receptor/Fc Recombinant Protein Growth Hormone Receptor GHR Human Growth Hormone Receptor/Fc Recombinant Human Growth Hormone Receptor/Fc Recombinant Human Growth Hormone Receptor/Fc |
| Target | GHR |
| Applications | ELISA Cap |
| Storage | -20°C to -70°C |
| Protein | GHR |