Recombinant Human GMFB (G629-GRP)

Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa neurotrophic protein pivotal for brain development, nervous system differentiation, and nerve regeneration. As a member of the actin-depolymerizing factor (ADF) family, GMF-Beta regulates cytoskeletal dynamics influencing both glial and neuronal cell maturation. GMF-Beta stimulates differentiation of normal neurons and glial cells while inhibiting proliferation of neuroblastoma and glioma tumor cell lines, promoting phenotypic expression and tumor suppression in cell culture. Produced primarily by astrocytes and thymic epithelial cells, GMF-Beta plays a crucial role in neural development as well as T cell maturation favoring CD4+ subsets. Unlike secreted growth factors, GMF-Beta functions at close cell-cell contact due to limited secretion. Emerging research identifies GMF-Beta as a modulator of inflammatory cytokine production, linking it to neuroinflammation and autoimmune disease progression. This brain-specific protein is essential for maintaining nervous system homeostasis and offers potential targets for neurodegenerative disease and cancer therapies.