Recombinant Human Galectin-4 (G703-50ug)

Galectin-4, also known as GAL4, belongs to a family of carbohydrate-binding proteins. It is a transcriptional activator which controls expression of the genes necessary for galactose catabolism. GAL4 is composed of two carbohydrate recognition domains within the same peptide chain. Both domains bind lactose with a similar affinity as other galectins but their respective preferences for other disaccharides, and larger saccharides, are distinctly different (1). During development and in adult normal tissues GAL4 is expressed only in the alimentary tract from the tongue to the large intestine (2). It is often found in relatively insoluble complexes, as a component of either adherens junctions or lipid rafts in the microvillus membrane, and it has been proposed to stabilize these structures (3). GAL4 can also bind lung, spleen and kidney macrophages, although its expression is normally low in these tissues. However, strong expression of GAL4 can be induced in cancers from other tissues including breast and liver (4). In cultured cells, intracellular GAL4 may promote resistance to nutrient starvation, whereas, as an extracellular protein, it can mediate cell adhesion. Because of its distinct induction in breast and other cancers, it may be a valuable diagnostic marker and target for the development of inhibitory carbohydrate-based drugs.