Recombinant Human FGF R4

Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity¹ that is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous.² FGFR4 plays essential roles in systemic lipid and glucose homeostasis.³ FGFR4 may be an important regulator of osteogenesis with involvement in preosteoblast proliferation and differentiation as well as osteoblast functioning during intramembranous ossification.⁴ FGFR-4 signaling and receptor turnover are important potential therapeutic targets in prostate cancer.²